Okayama University of Science, Veterinary Biochemistry Lab, Tanaka group

Neuropathology and Cell biology

Molecular neuropathology for neurodegenerative diseases (FTLD/ALS) characteristic of TDP-43 accumulation

TDP-43 is a nuclear protein essential for survival of cells. Importantly, TDP-43 is mislocalized and aggregated in the cytoplasm from the nucleus, which causes neurodegenerative diseases such as Frontotemporal lobar degeneration (FTLD) or Amyotrophic lateral sclerosis (ALS). Pathological TDP-43 in the brain of patients has prion-like property that causes seed-dependent TDP-43 aggregation. Moreover, its property enables TDP-43 to propagate through the neuronal network with aging. Our aim is to reveal the process that TDP-43 gains the prion-like property, and to develop the strategy to prevent or remedy TDP-43 proteinopathy.

News

29/3/2024 Our paper accepted from Biochemistry and Biophysics Reports.

29/3/2024 Tanaka had a oral presentation about TDP-43 proteinopathy.

13/3/2024 Kikuchi and Kusumoto passed the exam for qualification of veterinary medicine. They become an animal doctor! CONGRATS!!!

1/3/2024 Tanaka and Ito had a presentation in the research meeting about extracellular vesicles @Ehime University.

30/11/2023 Our paper accepted from Autophagy Reports

19/09/2023 Our paper accepted from JBC

16/11/2022 Our proposal accepted from the grant for young investigators in the field of pharmacopsychiatry of SENSHIN Medical Research Foundation

10/5/2022 Our paper accepted from BBRC

27/4/2022 Lina joined our Lab via ILAP

14/4/2022 Our paper accepted from BBRC

1/4/2022 Yuya (M) and Yuya (N) joined our Lab

10/08/2021 Yuki joined our Lab via ILAP

12/07/2021 Our proposal accepted from Takeda Science Foundation

04/06/2021 Our proposal accepted from Wesco Scientific Promotion Foundation

19/4/2021　Shun-ichi joined our Lab via ILAP

1/4/2021　　Misaki and Shun-ya joined our Lab

Upcoming

Tanaka will have a presentation at Neuro2024 held in my hometown Fukuoka.

Tanaka will have a presentation at the 65th regional meeting of Chugoku-Shikoku area of Japanese Biochemical Society held in Shimane Univ.

Our proposal about holding the symposium about FTLD-TDP at 47th meeting of Japanese Molecular Biology Society was accepted! Our 5 presenters will appear to introduce their study and discuss the mechanism of FTLD-TDP.

26/08/2023 Dr. Tanaka had a presentation in the JSPS internatinal meeting held at National Taiwan University

Dr. Tanaka, B6 Kikuchi, B6 Kusumoto, and B4 Ito will have a oral presentation at the 6th progranulin meeting

The 6th progranulin meeting will be held on May 27th, 2023 at the department of veterinary medicine of Okayama Univ. of Sci. (Imabari, Ehime, Japan)

Dr. Tanaka and B3 Ito will have a oral presentation in the 165th meeting of the Japanese Society of Veterinary Scinece at Azabu University

Dr. Tanaka will have a oral presentation in the Neuro2022 at Okinawa, Japan

Dr. Tanaka will have a oral presentation in the 5th progranulin workshop at Toyo University (on-line).

Dr. Tanaka will have a poster presentation in the 40th annual meeting of Japan Dementia Society (on-line)

Dr. Tanaka will have a oral presentation in the 94th annual meeting of Japan Biochemistry Society (on-line)

Dr. Tanaka will have a oral presentation in the 62th Chugoku and Shikoku regional meeting of Japanese Biochemical Society (on-line)

Dr. Tanaka will have a poster presentation in the 44th annual meeting of Japan Neuroscience Society (on-line)