Neuropathology and Cell biology
Information from Dr. Tanaka group
Molecular neuropathology for neurodegenerative diseases (FTLD/ALS) characteristic of TDP-43 accumulation
TDP-43 is a nuclear protein essential for survival of cells. Importantly, TDP-43 is mislocalized and aggregated in the cytoplasm from the nucleus, which causes neurodegenerative diseases such as Frontotemporal lobar degeneration (FTLD) or Amyotrophic lateral sclerosis (ALS). Pathological TDP-43 in the brain of patients has prion-like property that causes seed-dependent TDP-43 aggregation. Moreover, its property enables TDP-43 to propagate through the neuronal network with aging. Our aim is to reveal the process that TDP-43 gains the prion-like property, and to develop the strategy to prevent or remedy TDP-43 proteinopathy.
News
04/09/2025 The 168th Annual Meeting of the Japanese Society of Veterinary Science was held at the Seagaia Convention Center in Miyazaki, where Tanaka and Kosako presented their work.
01/06/2025 The 66th Chugoku–Shikoku Regional Meeting of the Japan Biochemical Society was held at Kochi University, where Tanaka presented their work.
24/05/2025 The 7th Progranulin Meeting took place at Ochanomizu University, where Tanaka and Kosako presented their work.
23/05/2025 A kickoff meeting for the AMED Drug Discovery and Development Support Program was held at Shibaura Institute of Technology. Tanaka and Kosako had a presentation.
20/03/2025 Matsuoka graduated from the Okayama Science University.
12/03/2025 Matsuoka passed the national veterinary examination.
28/11/2024 Tanaka held a mini-symposium entitled "re-thinking ethology of FTLD-TDP from the view of emerging function of causal proteins" at the 47th meeting of molecular biology
14/11/2024 Our proposal accepted from SENSHIN Medical Foundation
18/10/2024 Our paper (1st author: Shun-ichi Ito) accepted from Journal of Visualized Experiments.
05/07/2024 Our proposal accepted from Takeda Science Foundation
29/3/2024 Our paper accepted from Biochemistry and Biophysics Reports.
29/3/2024 Tanaka had a oral presentation about TDP-43 proteinopathy.
13/3/2024 Kikuchi and Kusumoto passed the exam for qualification of veterinary medicine. They become an animal doctor! CONGRATS!!!
1/3/2024 Tanaka and Ito had a presentation in the research meeting about extracellular vesicles @Ehime University.
30/11/2023 Our paper accepted from Autophagy Reports
19/09/2023 Our paper accepted from JBC
16/11/2022 Our proposal accepted from the grant for young investigators in the field of pharmacopsychiatry of SENSHIN Medical Research Foundation
10/5/2022 Our paper accepted from BBRC
27/4/2022 Lina joined our Lab via ILAP
14/4/2022 Our paper accepted from BBRC
1/4/2022 Yuya (M) and Yuya (N) joined our Lab
10/08/2021 Yuki joined our Lab via ILAP
12/07/2021 Our proposal accepted from Takeda Science Foundation
04/06/2021 Our proposal accepted from Wesco Scientific Promotion Foundation
19/4/2021 Shun-ichi joined our Lab via ILAP
1/4/2021 Misaki and Shun-ya joined our Lab
Upcoming