2024
Tanaka Y, Kozuma L, Hino H, Takeya K, Eto M. “Abemaciclib and Vacuolin-1 Decrease Aggregate-prone TDP-43 Accumulation by Accelerating Autophagic Flux” Biochemistry and Biophysics Reports, 38, 101705.
Tanaka Y, Ito S, Suzuki G. "TDP-43 secretion via extracellular vesicles is regulated by macroautophagy" Autophagy Reports, 3(1).
2023
Kirkbride AJ, Nilsson GY, Kim IJ, Takeya K, Tanaka Y, Tokumitsu H, Suizu F, Eto M. "PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis" Biomolecules, 13(12):1741.
Tanaka Y, Ito S, Honma Y, Hasegawa M, Kametani F, Suzuki G, Kozuma L, Takeya K, Eto M. "Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43" Journal of biological chemistry, 299(11):105272.
2022
Tanaka Y, Hino H, Takeya K, Eto M. “Abemaciclib and vacuolin-1 induce vacuole-like autolysosome formation - a new tool to study autophagosome-lysosome fusion” BBRC, 614, pp191-197.
Tanaka Y, Kusumoto S, Honma Y, Takeya K, Eto M. “Overexpression of progranulin increases pathological protein accumulation by suppressing autophagic flux” BBRC, 611, pp78-84.
Eto M, Katsuki S, Ohashi M, Miyagawa Y, Tanaka Y, Takeya K, Kitazawa T. “Possible roles of N- and C-terminal unstructured tails of CPI-17 in regulating Ca2+ sensitization force of smooth muscle” J Smooth Muscle Res., 58, pp22-33.
2020
Kuroda M, Hosokawa M, Tanaka Y, Yamanouchi K, Nishihara M. “Convulsive responses to seizure-inducible drugs are exacerbated in progranulin-deficient mice” NeuroReport, 31, pp478-83.
Eto M, Katsuki S, Tanaka Y, Takeya K. “Kinase activity-tagged western blotting assay” BioTechniques, 68, pp211-213.
2019
Tanaka Y. Chapter-5. “Progranulin regulations of lysosomal homeostasis and its involvement in neurodegenerative diseases” Progranulin and Central Nervous System Disorders, Springer, 2019, 85-103.
2017
Hosokawa M, Tanaka Y, Arai T, Kondo H, Akiyama H, Hasegawa M. Progranulin haploinsufficiency reduces amyloid beta deposition Alzheimer’s disease model mice. Experimental Animals, 67, pp63-70.
Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M. Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes. Hum Mol Genet., 26, pp969-988.
2016
Tanaka Y, Hasegawa M. Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43. Prion, 10, pp283-9.
Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M. Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation. Hum Mol Genet., 25, pp1420-33.
Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M. Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43. J Biol Chem., 291, pp5473-83.
-2015
Kanazawa K, Kawamura K, Takahashi T, Miura M, Tanaka Y, Koyama M, Toriyabe M, Igarashi H, Nakada T, Nishihara M, Nishizawa M, Shimohata T. Multiple therapeutic effects of progranulin on experimental acute ischemic stroke. Brain., 138, pp1932-48, 2015
Tanaka Y, Chambers JK, Matsuwaki T, Yamanouchi K, Nishihara M. Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice. Acta Neuropathol Commun., 15, 2, 78, 2014
Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M. Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice. Neuroscience., 250, pp8-19, 2013
Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M. Exacerbated inflammatory responses related with activated microglia after traumatic brain injury in progranulin deficienct mice. Neuroscience., 231, pp49-60, 2013
Wu G, Matsuwaki T, Tanaka Y, Yamanouchi K, Hu J, Nishihara M. Taurine counteracts the suppressive effect of lipopolysaccharide on neurogenesis in the hippocampus of rats. Adv Exp Med Biol., 775, pp111-9, 2013
Tanaka Y and Kadokawa H. Providing a diet containing only maintenance levels of energy and protein during the latter stages of pregnancy resulted in a prolonged delivery time during parturition in rats. Reprod Fertil Dev., 24, pp317-322, 2012
Kadokawa H, Shibata M, Tanaka Y, Kojima T, Matsumoto K, Oshima K, Yamamoto N. Bovine C-terminal octapeptide of RFamide-related peptide-3 suppresses luteinizing hormone (LH) secretion from the pituitary as well as pulsatile LH secretion in bovines. Domest Anim Endocrinol., 36, pp219-24,